William Preston
William Preston may refer to:
- William Preston (Freemason) (1742–1818), Scottish author of Illustrations of Masonry
- William Preston (Virginia) (1729–1783), Irish-born frontier Virginia leader, signer of the Fincastle Resolutions
- William Preston (Kentucky) (1816–1887), U.S. politician, ambassador, and Confederate officer
- William Ballard Preston (1805–1862), U.S. politician from Virginia
- William B. Preston (Mormon) (1830–1908), Presiding Bishop of The Church of Jesus Christ of Latter-day Saints, 1884–1907
- William C. Preston (1794–1860), U.S. senator from the South Carolina
- William Campbell Preston (1794–1860), U.S. politician from Pennsylvania and Virginia
- William Preston (Royal Navy officer), captain in the British Royal Navy who, along with James Stirling, was responsible for the foundations of Perth and Fremantle in Western Australia
- William Preston (UK politician) (1874–1941), Conservative M.P. for Walsall, 1924–1929
- William Preston (actor) (1921–1998)
- William Alfred Preston (1848–1944), MPP in Ontario, Canada
- William G. Preston, American architect
- Billy Preston (1946–2006), American musician